A transcriptomic atlas of mouse neocortical layers.

Détails

ID Serval
serval:BIB_498CBFD849D0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A transcriptomic atlas of mouse neocortical layers.
Périodique
Neuron
Auteur⸱e⸱s
Belgard T.G., Marques A.C., Oliver P.L., Abaan H.O., Sirey T.M., Hoerder-Suabedissen A., García-Moreno F., Molnár Z., Margulies E.H., Ponting C.P.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2011
Volume
71
Numéro
4
Pages
605-616
Langue
anglais
Résumé
In the mammalian cortex, neurons and glia form a patterned structure across six layers whose complex cytoarchitectonic arrangement is likely to contribute to cognition. We sequenced transcriptomes from layers 1-6b of different areas (primary and secondary) of the adult (postnatal day 56) mouse somatosensory cortex to understand the transcriptional levels and functional repertoires of coding and noncoding loci for cells constituting these layers. A total of 5,835 protein-coding genes and 66 noncoding RNA loci are differentially expressed ("patterned") across the layers, on the basis of a machine-learning model (naive Bayes) approach. Layers 2-6b are each associated with specific functional and disease annotations that provide insights into their biological roles. This new resource (http://genserv.anat.ox.ac.uk/layers) greatly extends currently available resources, such as the Allen Mouse Brain Atlas and microarray data sets, by providing quantitative expression levels, by being genome-wide, by including novel loci, and by identifying candidate alternatively spliced transcripts that are differentially expressed across layers.
Mots-clé
Anatomy, Artistic, Animals, Atlases as Topic, Bayes Theorem, Gene Expression, Gene Expression Profiling, Mice, Microarray Analysis, RNA/metabolism, RNA, Untranslated/metabolism, Somatosensory Cortex/anatomy & histology, Somatosensory Cortex/chemistry
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/10/2014 14:46
Dernière modification de la notice
20/08/2019 13:56
Données d'usage