The acallosal mouse strain I/LnJ: a putative model of ADHD?

Détails

ID Serval
serval:BIB_4960CFC0560F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The acallosal mouse strain I/LnJ: a putative model of ADHD?
Périodique
Neuroscience and Biobehavioral Reviews
Auteur(s)
Magara Fluvio, Ricceri Laura, Wolfer David P., Lipp Hans-Peter
ISSN
0149-7634
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
24
Numéro
1
Pages
45-50
Langue
anglais
Notes
SAPHIRID:67378
Résumé
ADHD has been sometimes associated to a defective interhemispheric cross-talk caused by hypoplasia of the corpus callosum. The inbred mouse strain I/LnJ shows total callosal agenesis with complete penetrance, and behavioral features which resemble ADHD. In conditioned learning tasks, as well as in paradigms of spontaneous behavior. I/LnJ mice, as compared to other inbred strains, show lower learning scores, impulsiveness, and significantly higher locomotor activity, albeit with considerable individual variations. In order to disentangle the influences of the genetic background from the effects of the callosal agenesis, we undertook crossing studies between I/LnJ and C57BL/6 mice, obtaining hybrids with missing corpus callosum. In comparison to normal C57BL/6 mice, acallosal hybrids exposed to a novel open-field showed a different locomotor pattern, with less short stops and more center crossing during the beginning of the session. In a metabolic mapping study, the tendency of acallosals to stay off the walls was found to be associated to lower 2-deoxyglucose uptake in the left striatum and cerebral cortex, while the number of short stops was correlated to the bilateral levels of 2-deoxyglucose uptake in the frontal and parietal cortex. The results hint at a right hemisphere dominance in impulsiveness and hyperactivity, boosted by the lack of callosal connections.
Pubmed
Web of science
Création de la notice
11/03/2008 12:27
Dernière modification de la notice
20/08/2019 14:56
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