Subunit assembly and posttranslational processing of Na(+)-pumps

Détails

ID Serval
serval:BIB_493DA5446E9F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Subunit assembly and posttranslational processing of Na(+)-pumps
Périodique
Acta Physiologica Scandinavica. Supplementum
Auteur(s)
Geering  K.
ISSN
0302-2994 (Print)
Statut éditorial
Publié
Date de publication
1992
Volume
607
Pages
177-81
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Assembly, posttranslational processing and intracellular transport of Na,K-ATPase subunits are closely linked processes. Only coexpression of alpha- and beta-subunits in Xenopus oocytes permits the structural maturation and the ER exit of the two subunits. A putative beta 3-isoform of Na,K-ATPase and the beta-subunit of H,K-ATPase can support similar functions to those of beta 1-subunits of Na,K-ATPase in allowing the functional expression of alpha-beta complexes with Na,K-pump transport properties in the plasma membrane. These data indicate that a primary role of the beta subunit is to impose a conformational change on the newly synthesized alpha-subunits probably involved in the acquisition of transport competence and functional maturity of the catalytic alpha-subunit.
Mots-clé
Animals Isoenzymes/metabolism Na(+)-K(+)-Exchanging ATPase/*biosynthesis/*physiology Oocytes/enzymology Ouabain/metabolism Protein Binding *Protein Processing, Post-Translational Xenopus
Pubmed
Création de la notice
24/01/2008 13:28
Dernière modification de la notice
20/08/2019 14:56
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