Long-range heterogeneity at the 3' ends of human mRNAs.

Détails

ID Serval
serval:BIB_489DD81FECC4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Institution
Titre
Long-range heterogeneity at the 3' ends of human mRNAs.
Périodique
Genome Research
Auteur⸱e⸱s
Iseli C., Stevenson B.J., de Souza S.J., Samaia H.B., Camargo A.A., Buetow K.H., Strausberg R.L., Simpson A.J., Bucher P., Jongeneel C.V.
ISSN
1088-9051[print], 1088-9051[linking]
Statut éditorial
Publié
Date de publication
2002
Volume
12
Numéro
7
Pages
1068-1074
Langue
anglais
Notes
Publication types: Letter
Publication Status: ppublish
Résumé
The publication of a draft of the human genome and of large collections of transcribed sequences has made it possible to study the complex relationship between the transcriptome and the genome. In the work presented here, we have focused on mapping mRNA 3' ends onto the genome by use of the raw data generated by the expressed sequence tag (EST) sequencing projects. We find that at least half of the human genes encode multiple transcripts whose polyadenylation is driven by multiple signals. The corresponding transcript 3' ends are spread over distances in the kilobase range. This finding has profound implications for our understanding of gene expression regulation and of the diversity of human transcripts, for the design of cDNA microarray probes, and for the interpretation of gene expression profiling experiments.
Mots-clé
3' Flanking Region/genetics, Genetic Heterogeneity, Humans, RNA, Messenger/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 16:39
Dernière modification de la notice
20/08/2019 14:55
Données d'usage