New genes controlling human reproduction and how you find them.

Détails

ID Serval
serval:BIB_4893C9AF0B85
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
New genes controlling human reproduction and how you find them.
Périodique
Transactions of the American Clinical and Climatological Association
Auteur(s)
Crowley W.F., Pitteloud N., Seminara S.
ISSN
0065-7778 (Print)
ISSN-L
0065-7778
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
119
Pages
29-37; discussion 37-8
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
The neuroendocrine control of reproduction in all mammals is governed by a hypothalamic neural network of approximately 1,500 gonadotropin releasing hormone (GnRH) secreting neurons that control activity of the reproductive axis across life. Recently, the syndrome of human GnRH deficiency, either with anosmia, termed Kallmann Syndrome (KS), or with a normal sense of smell, termed normosmic Idiopathic Hypogonadotropic Hypogonadism (nIHH), have proven important disease models that have revealed much about the abnormalities that can befall the GnRH neurons as they differentiate, migrate, form networks, mature and senesce. Mutations in several genes responsible for these highly coordinated developmental processes have thus been unearthed by the study of this prismatic disease model. This paper discusses several of the more important discoveries in this rapidly evolving field and puts them into a developmental and physiologic context.
Mots-clé
Animals, Extracellular Matrix Proteins/genetics, Extracellular Matrix Proteins/physiology, Female, Gastrointestinal Hormones/genetics, Gastrointestinal Hormones/physiology, Gonadotropin-Releasing Hormone/deficiency, Gonadotropin-Releasing Hormone/genetics, Humans, Hypothalamus/physiology, Kisspeptins, Male, Mice, Mice, Knockout, Mutation, Nerve Net/physiology, Nerve Tissue Proteins/genetics, Nerve Tissue Proteins/physiology, Neuropeptides/genetics, Neuropeptides/physiology, Receptor, Fibroblast Growth Factor, Type 1/genetics, Receptor, Fibroblast Growth Factor, Type 1/physiology, Receptors, G-Protein-Coupled/genetics, Receptors, G-Protein-Coupled/physiology, Receptors, Peptide/genetics, Receptors, Peptide/physiology, Reproduction/genetics, Reproduction/physiology, Tumor Suppressor Proteins/genetics, Tumor Suppressor Proteins/physiology
Pubmed
Création de la notice
03/12/2014 15:31
Dernière modification de la notice
20/08/2019 13:55
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