Antivirale Therapie und Resistenzentwicklung am Beispiel der HIV-Infektion. [Antiviral therapy and resistance formation exemplified by HIV infection]

Détails

ID Serval
serval:BIB_4878CA8B4976
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antivirale Therapie und Resistenzentwicklung am Beispiel der HIV-Infektion. [Antiviral therapy and resistance formation exemplified by HIV infection]
Périodique
Therapeutische Umschau
Auteur(s)
Furrer  H., Telenti  A.
ISSN
0040-5930 (Print)
Statut éditorial
Publié
Date de publication
10/2003
Volume
60
Numéro
10
Pages
631-5
Notes
English Abstract
Journal Article --- Old month value: Oct
Résumé
In the last few years the antiretroviral combination therapy has drastically reduced the mortality and morbidity in HIV-infected patients. The aim of this treatment is the suppression of viral replication by a combination of at least three active drugs. However, about 20-40% of the patients experience a virological treatment failure, mostly due to development of drug resistant viruses on the background of insufficient drug levels. This resistances can be detected geno- and phenotypically by validated techniques. In the individual case of treatment failure resistance testing and therapeutic drug monitoring can help to find the most appropriate drug combination in the right dosage.
Mots-clé
Anti-HIV Agents/pharmacokinetics/*therapeutic use CD4 Lymphocyte Count Dose-Response Relationship, Drug Drug Monitoring *Drug Resistance, Viral Drug Therapy, Combination HIV/drug effects HIV Infections/*drug therapy Humans Virus Replication/drug effects
Pubmed
Création de la notice
25/01/2008 14:46
Dernière modification de la notice
20/08/2019 13:55
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