Carotid atherosclerosis and risk of subsequent coronary event in outpatients with atherothrombosis

Détails

ID Serval
serval:BIB_4845513A64A1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Carotid atherosclerosis and risk of subsequent coronary event in outpatients with atherothrombosis
Périodique
Stroke
Auteur⸱e⸱s
Sirimarco G., Amarenco P., Labreuche J., Touboul P. J., Alberts M., Goto S., Rother J., Mas J. L., Bhatt D. L., Steg P. G.
Collaborateur⸱rice⸱s
Reach Registry Investigators
ISSN
1524-4628 (Electronic)
ISSN-L
0039-2499
Statut éditorial
Publié
Date de publication
02/2013
Peer-reviewed
Oui
Volume
44
Numéro
2
Pages
373-9
Langue
anglais
Notes
Sirimarco, Gaia
Amarenco, Pierre
Labreuche, Julien
Touboul, Pierre-Jean
Alberts, Mark
Goto, Shinya
Rother, Joachim
Mas, Jean-Louis
Bhatt, Deepak L
Steg, Philippe Gabriel
eng
Research Support, Non-U.S. Gov't
Stroke. 2013 Feb;44(2):373-9. doi: 10.1161/STROKEAHA.112.673129. Epub 2013 Jan 10.
Résumé
BACKGROUND AND PURPOSE: The presence of carotid plaque reflects overall atherosclerotic burden and may predict coronary artery disease events. We examined the association among carotid atherosclerosis, history of atherothrombotic events, and risk of coronary events. METHODS: Among 45 227 patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry with 4-year follow-up, 23 364 patients with information on carotid atherosclerosis at baseline were analyzed. The primary outcome was the composite of first occurrence of cardiovascular death, myocardial infarction, or coronary hospitalization. RESULTS: The carotid atherosclerosis was present in 46% of patients (n=10 725) and was associated with increasing conventional cardiovascular risk factors and extent of symptomatic vascular disease. During 4-year follow-up, 4304 patients experienced >/=1 coronary event. After adjustment for cardiovascular risk factors and geographic region, the risk of coronary events increased by 22% (95% confidence interval [CI], 14%-30%) in patients with versus without carotid atherosclerosis. The relative increase was 18% (95% CI, -7%-51%) in patients enrolled with multiple risk factors only, 25% (95% CI,16%-35%) in patients with coronary artery disease, 46% (95% CI,28%-65%) in patients with cerebrovascular disease, and 37% (95% CI,17%-60%) in patients with peripheral artery disease. Carotid atherosclerosis was associated with increased risk, even among patients with previous myocardial infarction but no known stroke (P=0.001) or among patients with previous stroke but no known myocardial infarction (P<0.001). CONCLUSIONS: Carotid atherosclerosis was an independent predictor of coronary events across all types of symptomatic vascular disease and had an incremental effect on risk regardless of risk factors or location of vessel disease.
Mots-clé
Aged, Aged, 80 and over, *Ambulatory Care/trends, Carotid Artery Diseases/diagnosis/*epidemiology, Coronary Artery Disease/diagnosis/*epidemiology, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Registries, Risk Factors, Thrombosis/diagnosis/*epidemiology
Pubmed
Open Access
Oui
Création de la notice
28/02/2018 14:47
Dernière modification de la notice
20/08/2019 13:55
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