Salvage of ischemic myocardium: a focus on JNK

Détails

ID Serval
serval:BIB_46B52F80FD42
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Salvage of ischemic myocardium: a focus on JNK
Périodique
Advances in Experimental Medicine and Biology
Auteur(s)
Duplain  H.
ISSN
0065-2598 (Print)
Statut éditorial
Publié
Date de publication
2006
Volume
588
Pages
157-64
Notes
Journal Article
Review
Résumé
Myocardial infarction is a problem of utmost clinical significance, associated with an important morbidity and mortality. Actual treatment of this affection is focusing on the reperfusion of the occluded coronary-artery. A complementary approach would be to prevent the death of the ischemic myocardium by interacting with detrimental intracellular pathways. Several strategies have been successfully used to reduce the size of myocardial infarction in animal models. In this article, we will focus on the c-Jun N-terminal kinase (JNK), a member of the mitogen-activated (MAPK) protein kinase family and an important determinant of cell survival/death. We will review the role of JNK in cardiac ischemia/reperfusion and summarize recent advances in the use of JNK inhibitors to protect the myocardium.
Mots-clé
Animals Apoptosis Cell Death Cell Survival MAP Kinase Kinase 4/*physiology MAP Kinase Signaling System Models, Biological Myocardial Infarction/*pathology Myocardial Ischemia/pathology/*therapy Myocardial Reperfusion Injury/pathology Myocardium/*enzymology/pathology Necrosis Rats Reperfusion Injury Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 13:44
Dernière modification de la notice
20/08/2019 13:52
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