Inhibitory receptor-mediated regulation of natural killer cells.

Détails

Ressource 1Télécharger: Crit Rev 9 revised author copy.pdf (390.23 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_4698362D418E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inhibitory receptor-mediated regulation of natural killer cells.
Périodique
Critical Reviews in Immunology
Auteur(s)
Alari-Pahissa E., Grandclement C., Jeevan-Raj B., Held W.
ISSN
1040-8401 (Print)
ISSN-L
1040-8401
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
34
Numéro
6
Pages
455-465
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Natural killer (NK) cells are capable of directly recognizing pathogens, pathogen-infected cells, and transformed cells. NK cells recognize target cells using approximately 100 germ-line encoded receptors, which display activating or inhibitory function. NK cell activation usually requires the engagement of more than one receptor, and these may contribute distinct signaling inputs that are required for the firm adhesion of NK cells to target cells, polarization, and the release of cytotoxic granules, as well as the production of cytokines. In this article we discuss receptor-mediated mechanisms that counteract NK cell activation. The distinct intracellular inhibitory signaling pathways and how they can dominantly interfere with NK cell activation signaling events are discussed first. In addition, mechanisms by which inhibitory receptors modulate cellular activation at the level of receptor-ligand interactions are described. Receptor-mediated inhibition of NK cell function serves three main purposes: ensuring tolerance of NK cells to normal cells, enabling NK cell responses to aberrant host cells that have lost an inhibitory ligand, and, finally, allowing the recognition of certain pathogens that do not express inhibitory ligands.
Pubmed
Web of science
Création de la notice
21/02/2015 14:03
Dernière modification de la notice
18/09/2020 6:08
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