Neurotensin receptors in human meningiomas.

Détails

ID Serval
serval:BIB_45F15CF93107
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neurotensin receptors in human meningiomas.
Périodique
Annals of Neurology
Auteur(s)
Przedborski S., Levivier M., Cadet J.L.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Statut éditorial
Publié
Date de publication
1991
Peer-reviewed
Oui
Volume
30
Numéro
5
Pages
650-654
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We have investigated the presence of neurotensin receptors in human meningiomas by in vitro binding autoradiography. Ten of the 12 meningiomas tested displayed specific [3H]neurotensin binding. All meningothelial (n = 3) and transitional (n = 5) meningiomas were positive, whereas only 2 of the 4 fibroblastic meningiomas showed measurable concentrations of neurotensin binding sites. Within the tumors, [3H]neurotensin binding was preferentially observed in syncytial areas. Saturation experiments showed that the maximal binding capacity (Bmax) greatly varied among tumors, ranging from low values to more than 290 fmol/mg of protein. All positive tumors had neurotensin binding sites with a dissociation constant (kd) within the nanomolar range and a pharmacological specificity for [3H]neurotensin similar to neurotensin receptors.
Mots-clé
Adult, Female, Humans, Male, Meningeal Neoplasms/chemistry, Meningioma/chemistry, Neoplasm Proteins/analysis, Neurotensin/metabolism, Receptors, Neurotensin, Receptors, Neurotransmitter/analysis, Tumor Markers, Biological/analysis
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
20/08/2019 14:51
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