Social buffering in rats reduces fear by oxytocin triggering sustained changes in central amygdala neuronal activity.

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Accès restreint UNIL
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_45B6B94482E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Social buffering in rats reduces fear by oxytocin triggering sustained changes in central amygdala neuronal activity.
Périodique
Nature communications
Auteur⸱e⸱s
Hegoburu C., Tang Y., Niu R., Ghosh S., Triana Del Rio R., de Araujo Salgado I., Abatis M., Alexandre Mota Caseiro D., van den Burg E.H., Grundschober C., Stoop R.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
07/03/2024
Peer-reviewed
Oui
Volume
15
Numéro
1
Pages
2081
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The presence of a companion can reduce fear, but the neural mechanisms underlying this social buffering of fear are incompletely known. We studied social buffering of fear in male and female, and its encoding in the amygdala of male, auditory fear-conditioned rats. Pharmacological, opto,- and/or chemogenetic interventions showed that oxytocin signaling from hypothalamus-to-central amygdala projections underlied fear reduction acutely with a companion and social buffering retention 24 h later without a companion. Single-unit recordings with optetrodes in the central amygdala revealed fear-encoding neurons (showing increased conditioned stimulus-responses after fear conditioning) inhibited by social buffering and blue light-stimulated oxytocinergic hypothalamic projections. Other central amygdala neurons showed baseline activity enhanced by blue light and companion exposure, with increased conditioned stimulus responses that persisted without the companion. Social buffering of fear thus switches the conditioned stimulus from encoding "fear" to "safety" by oxytocin-mediated recruitment of a distinct group of central amygdala "buffer neurons".
Mots-clé
Rats, Male, Female, Animals, Conditioning, Psychological/physiology, Oxytocin, Central Amygdaloid Nucleus, Rats, Wistar, Fear/physiology, Neurons
Pubmed
Open Access
Oui
Création de la notice
11/03/2024 12:25
Dernière modification de la notice
09/08/2024 15:52
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