Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

Détails

ID Serval
serval:BIB_4532
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Hentze M.W., Kühn L.C.
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
1996
Volume
93
Numéro
16
Pages
8175-8182
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in biology and medicine. At the cellular level, the basic molecular framework for the regulation of iron uptake, storage, and utilization has been defined. Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs). Nitric oxide (NO) and oxidative stress in the form of H2O2 also signal to IRPs and thereby influence cellular iron metabolism. The recent discovery of two IRE-regulated mRNAs encoding enzymes of the mitochondrial citric acid cycle may represent the beginnings of elucidating regulatory coupling between iron and energy metabolism. In addition to providing insights into the regulation of iron metabolism and its connections with other cellular pathways, the IRE/IRP system has emerged as a prime example for the understanding of translational regulation and mRNA stability control. Finally, IRP-1 has highlighted an unexpected role for iron sulfur clusters as post-translational regulatory switches.
Mots-clé
Animals, Base Sequence, Binding Sites, Ferritins/genetics, Gene Expression Regulation, Homeostasis, Iron/metabolism, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Iron-Regulatory Proteins, Iron-Sulfur Proteins/physiology, Mitochondria/enzymology, Molecular Sequence Data, Nitric Oxide/metabolism, Nucleic Acid Conformation, Oxidation-Reduction, Oxidative Stress, Protein Biosynthesis, RNA Processing, Post-Transcriptional, RNA, Messenger/metabolism, RNA-Binding Proteins/physiology, Receptors, Transferrin/genetics, Regulatory Sequences, Nucleic Acid
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 12:40
Dernière modification de la notice
20/08/2019 13:49
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