Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.

Détails

ID Serval
serval:BIB_451E57E39BC7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.
Périodique
European journal of neurology
Auteur(s)
Gensicke H., Wicht A., Bill O., Zini A., Costa P., Kägi G., Stark R., Seiffge D.J., Traenka C., Peters N., Bonati L.H., Giovannini G., De Marchis G.M., Poli L., Polymeris A., Vanacker P., Sarikaya H., Lyrer P.A., Pezzini A., Vandelli L., Michel P., Engelter S.T.
Collaborateur(s)
Thrombolysis in Stroke Patients (TriSP) collaborators
ISSN
1468-1331 (Electronic)
ISSN-L
1351-5101
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
23
Numéro
12
Pages
1705-1712
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The impact of body mass index (BMI) on outcome in stroke patients treated with intravenous thrombolysis (IVT) was investigated.
In a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage (sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m2 ) from underweight (<18.5 kg/m2 ), overweight (25-29.9 kg/m2 ) and obese (≥30 kg/m2 ) patients. Univariable and multivariable regression analyses with adjustments for age and stroke severity were done and odds ratios with 95% confidence intervals [OR (95% CI)] were calculated.
Of 1798 patients, 730 (40.6%) were normal weight, 55 (3.1%) were underweight, 717 (39.9%) overweight and 295 (16.4%) obese. Poor outcome occurred in 38.1% of normal weight patients and did not differ significantly from underweight (45.5%), overweight (36.1%) and obese (32.5%) patients. The same was true for death (9.5% vs. 14.5%, 9.6% and 7.5%) and sICH (3.9% vs. 5.5%, 4.3%, 2.7%). Neither in univariable nor in multivariable analyses did the risks of poor outcome, death or sICH differ significantly between BMI groups. BMI as a continuous variable was not associated with poor outcome, death or sICH in unadjusted [OR (95% CI) 0.99 (0.97-1.01), 0.98 (0.95-1.02), 0.98 (0.94-1.04)] or adjusted analyses [OR (95% CI) 1.01 (0.98-1.03), 0.99 (0.95-1.05), 1.01 (0.97-1.05)], respectively.
In this largest study to date, investigating the impact of BMI in IVT-treated stroke patients, BMI had no prognostic meaning with regard to 3-month functional outcome, death or occurrence of sICH.

Mots-clé
Aged, Aged, 80 and over, Body Mass Index, Brain Ischemia/drug therapy, Female, Humans, Infusions, Intravenous, Intracranial Hemorrhages/etiology, Male, Middle Aged, Prognosis, Risk, Stroke/drug therapy, Thrombolytic Therapy/adverse effects, Treatment Outcome, body mass index, intravenous thrombolysis, outcome, stroke, symptomatic intracranial haemorrhage
Pubmed
Web of science
Création de la notice
04/08/2016 17:18
Dernière modification de la notice
20/08/2019 13:49
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