Main objectives and new aspects of combination treatment of hypertension

Détails

ID Serval
serval:BIB_45175EBC429C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Main objectives and new aspects of combination treatment of hypertension
Périodique
Journal of Hypertension. Supplement
Auteur(s)
Waeber B., Brunner  H. R.
ISSN
0952-1178
Statut éditorial
Publié
Date de publication
1995
Volume
13
Numéro
2
Pages
S15-9
Langue
anglais
Notes
Journal Article
Review
Résumé
AIM: To review the various pharmacological approaches currently proposed for the treatment of hypertension. RESULTS: With the evolution of pharmacological treatment of hypertension, various classes of agent (diuretics, beta-blockers, angiotensin converting enzyme inhibitors, calcium antagonists and alpha 1-blockers) have become available for the initiation of antihypertensive therapy. As monotherapy, each type of agent will normalize blood pressure in about half of all hypertensive patients. Replacing one drug with another that acts through a different mechanism improves the probability of controlling blood pressure. Another way to increase the number of responders is to increase the dose; however, this often results in more side effects. A preferable way of improving efficacy is to combine low doses of drugs that have different impacts on the cardiovascular system, thus opposing the compensatory responses that tend to limit the blood pressure drop. CONCLUSION: Low-dose drug combinations are generally well tolerated and the treatment of hypertension can be simplified by using fixed-dose combinations. These combinations have the potential to become a valuable alternative in the initiation of antihypertensive therapy.
Mots-clé
Adrenergic alpha-Antagonists/administration & dosage/adverse effectsAdrenergic beta-Antagonists/administration & dosage/adverse effectsAngiotensin-Converting Enzyme Inhibitors/administration & dosage/adverseeffectsAntihypertensive Agents/*administration & dosage/adverse effectsBlood Pressure/drug effectsCalcium Channel Blockers/administration & dosage/adverse effectsDiuretics/administration & dosage/adverse effectsDrug Therapy, CombinationHumansHypertension/*drug therapy/etiologyRandomized Controlled Trials as Topic
Pubmed
Web of science
Création de la notice
06/03/2009 12:01
Dernière modification de la notice
20/08/2019 13:49
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