Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.

Détails

ID Serval
serval:BIB_45100BE4016B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.
Périodique
Journal of Alzheimer's Disease
Auteur(s)
Koshy B., Miyashita A., St Jean P., Stirnadel H., Kaise T., Rubio J.P., Mooser V., Kuwano R., Irizarry M.C.
ISSN
1875-8908 (Electronic)
ISSN-L
1387-2877
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
21
Numéro
3
Pages
775-780
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene - PLA2G7 V279F - is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of AD: logistic regression OR 0.98 (95% CI 0.86-1.12, p=0.81) per additional null allele, adjusted for age/age at onset, gender, and APOE ε4. Genetic deficiency of Lp-PLA2 activity is not associated with a reduced risk of AD in the Japanese population.
Mots-clé
Alleles, Alzheimer Disease/genetics, Apolipoproteins E/genetics, Asian Continental Ancestry Group/genetics, Gene Frequency, Genetic Predisposition to Disease, Humans, Japan, Mutation, Phospholipases A2/genetics, Polymorphism, Genetic, Risk
Pubmed
Web of science
Création de la notice
21/01/2013 10:56
Dernière modification de la notice
20/08/2019 13:49
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