Trends in Incidences and Risk Factors for Hepatocellular Carcinoma and Other Liver Events in HIV and Hepatitis C Virus-coinfected Individuals From 2001 to 2014: A Multicohort Study.

Détails

ID Serval
serval:BIB_44D59ED27592
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Trends in Incidences and Risk Factors for Hepatocellular Carcinoma and Other Liver Events in HIV and Hepatitis C Virus-coinfected Individuals From 2001 to 2014: A Multicohort Study.
Périodique
Clinical infectious diseases
Auteur⸱e⸱s
Gjærde L.I., Shepherd L., Jablonowska E., Lazzarin A., Rougemont M., Darling K., Battegay M., Braun D., Martel-Laferriere V., Lundgren J.D., Rockstroh J.K., Gill J., Rauch A., Mocroft A., Klein M.B., Peters L.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Statut éditorial
Publié
Date de publication
15/09/2016
Peer-reviewed
Oui
Volume
63
Numéro
6
Pages
821-829
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
While liver-related deaths in human immunodeficiency virus (HIV) and hepatitis C virus (HCV)-coinfected individuals have declined over the last decade, hepatocellular carcinoma (HCC) may have increased. We describe the epidemiology of HCC and other liver events in a multicohort collaboration of HIV/HCV-coinfected individuals.
We studied HCV antibody-positive adults with HIV in the EuroSIDA study, the Southern Alberta Clinic Cohort, the Canadian Co-infection Cohort, and the Swiss HIV Cohort study from 2001 to 2014. We calculated the incidence of HCC and other liver events (defined as liver-related deaths or decompensations, excluding HCC) and used Poisson regression to estimate incidence rate ratios.
Our study comprised 7229 HIV/HCV-coinfected individuals (68% male, 90% white). During follow-up, 72 cases of HCC and 375 other liver events occurred, yielding incidence rates of 1.6 (95% confidence interval [CI], 1.3, 2.0) and 8.6 (95% CI, 7.8, 9.5) cases per 1000 person-years of follow-up, respectively. The rate of HCC increased 11% per calendar year (95% CI, 4%, 19%) and decreased 4% for other liver events (95% CI, 2%, 7%), but only the latter remained statistically significant after adjustment for potential confounders. Older age, cirrhosis, and low current CD4 cell count were associated with a higher incidence of both HCC and other liver events.
In HIV/HCV-coinfected individuals, the crude incidence of HCC increased from 2001 to 2014, while other liver events declined. Individuals with cirrhosis or low current CD4 cell count are at highest risk of developing HCC or other liver events.
Mots-clé
Adult, Carcinoma, Hepatocellular/complications, Carcinoma, Hepatocellular/epidemiology, Cohort Studies, Coinfection/complications, Coinfection/epidemiology, Female, HIV Infections/complications, HIV Infections/epidemiology, Hepatitis C/complications, Hepatitis C/epidemiology, Humans, Incidence, Liver Neoplasms/complications, Liver Neoplasms/epidemiology, Male, Risk Factors, HIV, cohort study, hepatitis C virus, hepatocellular carcinoma, liver disease
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/06/2016 10:11
Dernière modification de la notice
14/03/2020 6:26
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