Visual thalamocortical circuits in parvalbumin-deficient mice

Détails

ID Serval
serval:BIB_4497E1D4E92E
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Collection
Publications
Institution
Titre
Visual thalamocortical circuits in parvalbumin-deficient mice
Titre de la conférence
Brain Research
Auteur(s)
Lintas A., Schwaller B., Villa A.E.P.
Editeur
Elsevier BV
Adresse
Prague, Czech Republic
ISSN
0006-8993
Statut éditorial
Publié
Date de publication
11/2013
Peer-reviewed
Oui
Volume
1536
Pages
107-118
Langue
anglais
Résumé
The dorsal lateral geniculate nucleus (dLGN) is considered as the visual gateway to the visual cortex (VC) and sends collaterals to the thalamic reticular nucleus (RTN) that in turn receives collaterals of the corticofugal feedback projections. At all levels of this thalamocortical circuit there are GABAergic neurons expressing the calcium-buffer parvalbumin (PV). The present study reports for the first time the analysis of in vivo extracellular electrophysiological recordings performed simultaneously in dLGN, RTN and VC of anesthetized wild-type (WT) and parvalbumin-deficient (PVKO) mice. The firing rates of VC and RTN cells were increased in PVKO during spontaneous activity as well as in the presence of a photic stimulation (strobe flash at 2.5 Hz). Interestingly, dLGN cells in PVKO did not show significant changes in the rate of firing in comparison to WT. dLGN responses to the light flashes were characterized by ripples of inhibition and phasic excitation/rebound. We have analyzed the pattern of functional interactions between pairs of neighboring cells in VC, dLGN and RTN and across these areas in simultaneously recorded thalamocortical triplets, with one neuron from each area. We found that in PVKO the strength of the interactions tended to decrease locally, between neighboring cells, but tended to increase across the areas. The combination of these analyses provides new evidence on the important role played by PV-expression in regulating information processing in the central visual pathway suggesting that the ability to process information along parallel channels is decreased in the thalamocortical pathway of PV-deficient mice.
Mots-clé
Developmental Biology, General Neuroscience, Molecular Biology, Clinical Neurology
Pubmed
Web of science
Création de la notice
04/08/2017 8:48
Dernière modification de la notice
20/08/2019 13:49
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