Lack of thermogenic response to glucose/insulin infusion in diabetic obese subjects.

Détails

ID Serval
serval:BIB_44426B890DEE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lack of thermogenic response to glucose/insulin infusion in diabetic obese subjects.
Périodique
International Journal of Obesity
Auteur⸱e⸱s
Golay A., Schutz Y., Felber J.P., de Fronzo R.A., Jéquier E.
ISSN
0307-0565 (Print)
ISSN-L
0307-0565
Statut éditorial
Publié
Date de publication
1986
Volume
10
Numéro
2
Pages
107-116
Langue
anglais
Résumé
The change in energy expenditure consecutive to the infusion of glucose/insulin was examined in 17 non-obese (ten young, seven middle-aged) and 27 diabetic and non-diabetic obese subjects by employing the euglycemic insulin clamp technique in conjunction with continuous indirect calorimetry. The obese subjects were divided into four groups according to their response to a 100-g oral glucose test: group A, normal glucose tolerance; group B, impaired glucose tolerance; group C, diabetes with increased insulin response; group D, diabetes with reduced insulin response. The glucose/insulin infusion provoked an increase in energy expenditure in both young and middle-aged controls (+8.2 +/- 1.3 percent and +5.9 +/- 0.5 percent over the preinfusion baseline respectively), but a lower increase in the non-diabetic obese groups A and B (+4.0 +/- 0.7 percent and +2.0 +/- 1.0 percent over the preinfusion baseline respectively, P less than 0.05 and P less than 0.01 vs young controls). However, in the diabetic obese groups C and D, energy expenditure failed to increase in response to the glucose/insulin infusion (mean change: +0.1 +/- 1.0 percent and -2.0 +/- 1.9 percent (P less than 0.01, vs middle-aged) over the preinfusion baseline respectively). When the glucose-induced thermogenesis (GIT) was related to the glucose uptake--taking into account the hepatic glucose production--the GIT was found to be similarly reduced in the diabetics groups (C and D). The net change in the rate of energy expenditure was found to be significantly correlated with the rate of glucose uptake (r = +0.647, n = 44, P less than 0.001) when all the individuals were pooled. In conclusion, this study shows that the low glucose-induced thermogenesis in obese diabetics during glucose insulin infusion is mainly related to a reduced rate of glucose uptake; in addition, inhibition of gluconeogenesis by the glucose/insulin infusion may also contribute to decrease the thermogenic response.
Mots-clé
Adult, Body Temperature Regulation, Diabetes Mellitus/metabolism, Diabetes Mellitus/physiopathology, Female, Gluconeogenesis, Glucose/administration & dosage, Glucose/diagnostic use, Humans, Infusions, Parenteral, Insulin/administration & dosage, Insulin/diagnostic use, Insulin Resistance, Male, Middle Aged, Obesity
Pubmed
Web of science
Création de la notice
21/01/2008 14:09
Dernière modification de la notice
20/08/2019 14:48
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