Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis.

Détails

ID Serval
serval:BIB_442E105E9BB5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis.
Périodique
Psychological medicine
Auteur(s)
Lønfeldt N.N., Verhulst F.C., Strandberg-Larsen K., Plessen K.J., Lebowitz E.R.
ISSN
1469-8978 (Electronic)
ISSN-L
0033-2917
Statut éditorial
Publié
Date de publication
04/2019
Peer-reviewed
Oui
Volume
49
Numéro
6
Pages
881-890
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9 September 2018. We included English-language studies reporting results on the association between perinatal oxytocin exposure and any cognitive impairment, psychiatric symptoms or disorders in childhood. We assessed the quality of studies using the Newcastle-Ottawa Quality Assessment Scales. Independent risk estimates were pooled using random-effects meta-analyses when at least two independent datasets provided data on the same symptom or disorder. Otherwise, we provided narrative summaries. Two studies examined cognitive impairment, one examined problem behavior, three examined attention-deficit/hyperactivity disorder (ADHD) and seven focused on autism spectrum disorders (ASD). We provided narrative summaries of the studies on cognitive impairment. For ADHD, the pooled risk estimate was 1.17; 95% confidence interval (CI) 0.77-1.78, based on a pooled sample size of 5 47 278 offspring. For ASD, the pooled risk estimate was 1.10; 95% CI 1.04-1.17, based on 8 87 470 offspring. Conclusions that perinatal oxytocin increases the risks of neurodevelopmental problems are premature. Observational studies of low to high quality comprise the evidence-base, and confounding, especially by the genetic or environmental vulnerability, remains an issue. Current evidence is insufficient to justify modifying obstetric guidelines for the use of oxytocin, which state that it should only be used when clinically indicated.
Mots-clé
ADHD, ASD, adolescents, children, oxytocin, perinatal risk factors
Pubmed
Web of science
Création de la notice
07/02/2019 18:14
Dernière modification de la notice
20/08/2019 14:48
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