Family history of cancer, its combination with smoking and drinking, and risk of squamous cell carcinoma of the esophagus

Détails

ID Serval
serval:BIB_43FAFA6D65C6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Family history of cancer, its combination with smoking and drinking, and risk of squamous cell carcinoma of the esophagus
Périodique
Cancer Epidemiology, Biomarkers and Prevention
Auteur(s)
Garavello  Werner, Negri  Eva, Talamini  Renato, Levi  Fabio, Zambon  Paola, Dal Maso  Luigino, Bosetti  Cristina, Franceschi  Silvia, La Vecchia  Carlo
ISSN
1055-9965
Statut éditorial
Publié
Date de publication
2005
Volume
14
Numéro
6
Pages
1390-1393
Notes
Réf. IUMSP: R 05/72
SAPHIRID:47192 --- Old url value: http://cebp.aacrjournals.org/cgi/content/abstract/14/6/1390
Résumé
We analyzed the association between history of cancer in first-degree relatives and the risk of squamous cell carcinoma of the esophagus (SCCE) using data from three case-control studies conducted in Italy and Switzerland on 805 incident, histologically confirmed SCCE, and 3,461 hospital controls. The alcohol- and tobacco-adjusted odds ratio (OR) for a family history of esophageal cancer was 3.2 [95% confidence interval (CI), 1.7-6.2], and the OR was higher when the affected relative was a brother or was diagnosed at age <55 years. Compared to subjects without family history of esophageal cancer, noncurrent smokers, drinking <49 drinks per week, the OR was 2.9 (95% CI, 1.1-7.5) for family history alone, 15.5 (95% CI, 11.7-20.5) for current smokers drinking >/=49 drinks per week without family history of esophageal cancer, and 107.0 (95% CI, 13.0-880.2) for current smokers drinking >/=49 drinks per week who also had a family history of esophageal cancer. The risk of SCCE was also increased in subjects with a family history of cancer of the oral cavity/pharynx (OR, 3.7; 95% CI, 1.5-9.0) and stomach (OR, 2.0; 95% CI, 1.1-3.6), but not of other cancers, nor for a family history of any cancer (OR, 1.0; 95% CI, 0.8-1.4). These data show that, as for many other epithelial cancers, the risk of SCCE is increased in subjects with a family history of the disease, and that-in Western countries-avoidance of alcohol and tobacco is also the best way to prevent SCCE in subjects with a family history of the disease. [Authors]
Mots-clé
Alcohol Drinking , Carcinoma, Squamous Cell , Esophageal Neoplasms , Smoking
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/03/2008 9:28
Dernière modification de la notice
20/08/2019 13:48
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