Effect of bacterial immunization on experimental reflux nephropathy

Détails

ID Serval
serval:BIB_43DBBEF9E1D1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of bacterial immunization on experimental reflux nephropathy
Périodique
Journal of Urology
Auteur(s)
Torres  V. E., Kramer  S. A., Holley  K. E., Hartman  G. W., Bille  J., Ruiz-Arguelles  A., Ritts  R. E.
ISSN
0022-5347
Statut éditorial
Publié
Date de publication
04/1984
Peer-reviewed
Oui
Volume
131
Numéro
4
Pages
772-6
Notes
Journal Article --- Old month value: Apr
Résumé
This study was designed to test the hypothesis that young animals with vesicoureteral reflux might be more vulnerable to renal parenchymal infection by bacteria to which they had not been previously exposed. Forty-four crossbred male piglets had surgical induction of vesicoureteral reflux at 2 weeks of age and introduction of urinary tract infection at 6 weeks. They were sacrificed at 12 weeks of age. Between the ages of 2 and 6 weeks, 22 piglets received subcutaneous injections of formalin-killed Escherichia coli in incomplete Freund's adjuvant as described. The remaining 22 piglets received incomplete Freund's adjuvant and vehicle alone. The antibody responses to antigenic challenge were weak to moderate. Immunized animals tended to have less renal scarring and better renal tubular uptake of dimercaptosuccinic acid, in addition to significantly lower serum creatinine values (p less than 0.001) and less mesangial cell proliferation in glomeruli (p = 0.05). We conclude that previous exposure to a specific bacterial strain and bacterial immunization have at least a mild protective effect on the development of reflux nephropathy.
Mots-clé
Animals Escherichia coli/immunology *Immunization Kidney/pathology Kidney Diseases/etiology/pathology/*prevention & control Male Swine Urinary Tract Urinary Tract Infections/complications/pathology/*prevention & control Vesico-Ureteral Reflux/*complications/pathology
Pubmed
Web of science
Création de la notice
11/02/2008 13:39
Dernière modification de la notice
20/08/2019 14:48
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