Nerve stimulation augments angiotensin II overflow from canine gracilis muscle in vivo
Détails
ID Serval
serval:BIB_43DA4B19D87B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nerve stimulation augments angiotensin II overflow from canine gracilis muscle in vivo
Périodique
Journal of Hypertension
ISSN
0263-6352 (Print)
Statut éditorial
Publié
Date de publication
06/1991
Volume
9
Numéro
6
Pages
487-90
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
The overflow of endogenous angiotensin-(1-8)octapeptide (angiotensin II) from blood-perfused canine gracilis muscle vasculature in situ was studied. A positive veno-arterial concentration difference for angiotensin II over the gracilis muscle was found, indicating a net generation of angiotensin II under basal conditions. Angiotensin II levels in the venous effluent were elevated during 2 Hz (4-min) nerve stimulation, suggesting enhanced local angiotensin II generation both in the presence and absence of alpha-adrenoceptor blockade. Thus, our results in this in vivo model demonstrate a local overflow of angiotensin II from the skeletal muscle vasculature which can be enhanced by nerve stimulation. Whether this overflow of angiotensin II is due to conversion of circulating angiotensin I to angiotensin II or local de novo synthesis of angiotensin II remains to be established.
Mots-clé
Angiotensin II/*metabolism
Angiotensin-Converting Enzyme Inhibitors/pharmacology
Animals
Benzazepines/pharmacology
Dogs
Electric Stimulation
Female
Muscles/*metabolism
Receptors, Adrenergic, alpha/drug effects
Renin-Angiotensin System/physiology
Sympathetic Nervous System/*physiology
Pubmed
Web of science
Création de la notice
05/03/2008 17:41
Dernière modification de la notice
20/08/2019 14:47