International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection.

Détails

ID Serval
serval:BIB_43AD7D98D4B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection.
Périodique
Journal of Thoracic and Cardiovascular Surgery
Auteur⸱e⸱s
Sarahrudi K., Estenne M., Corris P., Niedermayer J., Knoop C., Glanville A., Chaparro C., Verleden G., Gerbase M.W., Venuta F., Böttcher H., Aubert J.D., Levvey B., Reichenspurner H., Auterith A., Klepetko W.
ISSN
0022-5223
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
127
Numéro
4
Pages
1126-1132
Langue
anglais
Résumé
OBJECTIVE: A retrospective study involving 13 institutions was performed to assess the efficacy of conversion from cyclosporine (INN: ciclosporin) to tacrolimus. METHODS: Data from 244 patients were analyzed. Indications for conversion were recurrent-ongoing rejection (n = 110) and stage 1 to 3 bronchiolitis obliterans syndrome (n = 134). RESULTS: The incidence of acute rejection decreased significantly within 3 months after versus before the switch from cyclosporine to tacrolimus (P <.01). For patients with recurrent-ongoing rejection, the forced expiratory volume in 1 second decreased by 1.96% of predicted value per month (P =.08 vs zero slope) before and increased by 0.34% of predicted value per month (P =.32 vs zero slope) after conversion (P <.06). For patients with stage 1 to 3 bronchiolitis obliterans syndrome, a significant reduction of rejection episodes was observed (P <.01). In single transplant recipients a decrease of the forced expiratory volume in 1 second averaged 2.25% of predicted value per month (P <.01 vs zero slope) before and 0.29% of predicted value per month after conversion. Corresponding values for bilateral transplant recipients were 3.7% of predicted value per month (P <.01 vs zero slope) and 0.9% of predicted value per month (P = 0.04 vs zero slope), respectively. No significant difference in the incidence of infections within 3 months before and after conversion was observed. CONCLUSIONS: Conversion from cyclosporine to tacrolimus after lung transplantation is associated with reversal of recurrent-ongoing rejection. Conversion for bronchiolitis obliterans syndrome allows short-term stabilization of lung function in most patients.
Mots-clé
Acute Disease, Adult, Australia, Azathioprine, Bronchiolitis Obliterans, Canada, Chronic Disease, Cyclosporine, Drug Therapy, Combination, Europe, Female, Follow-Up Studies, Forced Expiratory Volume, Graft Rejection, Humans, Hypertension, Pulmonary, Immunosuppressive Agents, Incidence, Kidney, Lung Transplantation, Male, Middle Aged, Postoperative Complications, Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Retrospective Studies, Tacrolimus, Time Factors, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 13:54
Dernière modification de la notice
20/08/2019 14:47
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