Pharmacological doses of atrial natriuretic peptide ameliorate the acute renal dysfunction induced by systemic hypoxemia

Détails

ID Serval
serval:BIB_43647F4B2FFA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pharmacological doses of atrial natriuretic peptide ameliorate the acute renal dysfunction induced by systemic hypoxemia
Périodique
Journal of Pharmacology and Experimental Therapeutics
Auteur(s)
Wiesel  P. H., Semmekrot  B. A., Grigoras  O., Heumann  C., Guignard  J. P.
ISSN
0022-3565 (Print)
Statut éditorial
Publié
Date de publication
09/1990
Volume
254
Numéro
3
Pages
971-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
The acute renal effects of systemic hypoxemia and the ability of atrial natriuretic peptide (ANP) to reverse these effects were assessed in seven anesthetized and mechanically ventilated adult rabbits. Throughout the experiment, arterial pH, PaCO2 and HCO3 remained unchanged. Hypoxemia induced a significant increase in rabbit-ANP plasma levels from 151 +/- 26 to 246 +/- 65 pg/ml. During the normoxemic period (PaO2 = 131 +/- 12 mm Hg), glomerular filtration rate (GFR), renal blood flow (RBF), renal vascular resistance (RVR) and urinary sodium excretion (UNaV) were similar in both kidneys. The subsequent hypoxemic period (PaO2 = 30 +/- 1 mm Hg) caused a decrease in right and left kidney function: GFR, -26 +/- 5 and -29 +/- 6%; RBF, -17 +/- 9 and -29 +/- 8%; RVR, +28 +/- 16 and +59 +/- 30%; urine flow rate, -38 +/- 6 and -36 +/- 6%; and UNaV, -51 +/- 7 and -50 +/- 7%, respectively. Human-ANP infusion in the left renal artery (100 ng/min) during sustained systemic hypoxemia induced a significant improvement in GFR (+57 +/- 18%), RBF (+21 +/- 8%), RVR (-20 +/- 7%), urine flow rate (+151 +/- 27%) and UNaV (+270 +/- 48%) in the left experimental kidney, as compared with the preceding hypoxemic period. In contrast, the function of the right control kidney remained impaired.
Mots-clé
Animals Anoxemia/*complications Atrial Natriuretic Factor/blood/*therapeutic use Hemodynamic Processes/drug effects Infusions, Intravenous Kidney Diseases/*drug therapy/etiology Kidney Function Tests Rabbits
Pubmed
Web of science
Création de la notice
25/01/2008 17:12
Dernière modification de la notice
20/08/2019 14:47
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