IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism
Détails
ID Serval
serval:BIB_43345B83AA81
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism
Périodique
Journal of Immunology
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
04/2003
Volume
170
Numéro
7
Pages
3495-503
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr 1
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr 1
Résumé
Activation-induced cell death (AICD) of T cells is one of the major mechanisms of peripheral tolerance. The regulation of AICD by IL-4 is poorly understood. In this study, we report that AICD in IL-4-deficient T cells is significantly reduced compared with that in wild-type T cells. This impaired AICD correlates with the failure to induce degradation of cellular FLIP. IL-4-mediated enhancement of AICD and cellular FLIP degradation requires a Janus kinase/STAT-6 signaling pathway. Unexpectedly, these effects of IL-4 could be blocked by a neutralizing anti-IL-2 Ab, and addition of rIL-2 could completely restore the defective AICD in IL-4-deficient T cells. Furthermore, IL-4 regulates the T cell thresholds for IL-2 signaling during AICD. These data suggest that IL-4 promotes AICD via an IL-2-dependent mechanism.
Mots-clé
Adjuvants, Immunologic/deficiency/genetics/*physiology
Animals
Antigens, CD95/metabolism
Apoptosis/genetics/*immunology
CASP8 and FADD-Like Apoptosis Regulating Protein
Carrier Proteins/metabolism
Cells, Cultured
Drug Synergism
Fas Ligand Protein
Interleukin-2/*physiology
Interleukin-4/deficiency/genetics/*physiology
*Intracellular Signaling Peptides and Proteins
Ligands
*Lymphocyte Activation/genetics
Membrane Glycoproteins/biosynthesis
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Proto-Oncogene Proteins c-bcl-2/biosynthesis
Receptors, Antigen, T-Cell/physiology
STAT6 Transcription Factor
Signal Transduction/immunology
T-Lymphocyte Subsets/*cytology/*immunology/metabolism
Trans-Activators/deficiency/genetics/physiology
Up-Regulation/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 14:46