Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.

Détails

Ressource 1Télécharger: s41467-024-44866-3.pdf (6882.42 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_4235435871D0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.
Périodique
Nature communications
Auteur⸱e⸱s
Agius T., Emsley R., Lyon A., MacArthur M.R., Kiesworo K., Faivre A., Stavart L., Lambelet M., Legouis D., de Seigneux S., Golshayan D., Lazeyras F., Yeh H., Markmann J.F., Uygun K., Ocampo A., Mitchell S.J., Allagnat F., Déglise S., Longchamp A.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
05/02/2024
Peer-reviewed
Oui
Volume
15
Numéro
1
Pages
1073
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Identifiant FNS: SNSF-PZ00P3-185927 / SNSF-310030-176158
Résumé
Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perioperative care pathway designed to enhance surgical recovery. Despite widespread clinical use, preclinical and mechanistic studies on carbohydrate loading in surgical contexts are lacking. Here we demonstrate in ad libitum-fed mice that liquid carbohydrate loading for one week drives reductions in solid food intake, while nearly doubling total caloric intake. Similarly, in humans, simple carbohydrate intake is inversely correlated with dietary protein intake. Carbohydrate loading-induced protein dilution increases expression of hepatic fibroblast growth factor 21 (FGF21) independent of caloric intake, resulting in protection in two models of surgical stress: renal and hepatic ischemia-reperfusion injury. The protection is consistent across male, female, and aged mice. In vivo, amino acid add-back or genetic FGF21 deletion blocks carbohydrate loading-mediated protection from ischemia-reperfusion injury. Finally, carbohydrate loading induction of FGF21 is associated with the induction of the canonical integrated stress response (ATF3/4, NF-kB), and oxidative metabolism (PPARγ). Together, these data support carbohydrate loading drinks prior to surgery and reveal an essential role of protein dilution via FGF21.
Mots-clé
Animals, Female, Humans, Male, Mice, Diet, Carbohydrate Loading, Dietary Carbohydrates/metabolism, Dietary Proteins/metabolism, Fibroblast Growth Factors/metabolism, Liver/surgery, Liver/metabolism, Mice, Inbred C57BL, Reperfusion Injury/metabolism, Surgical Procedures, Operative
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse
Fonds national suisse
Fondation Novartis
Fondation Leenaards
Fonds national suisse
Création de la notice
06/02/2024 19:47
Dernière modification de la notice
26/07/2024 11:53
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