A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_420B9930D181
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue.
Périodique
Frontiers in Cellular Neuroscience
Auteur⸱e⸱s
Elsayed M., Magistretti P.J.
ISSN
1662-5102 (Electronic)
ISSN-L
1662-5102
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
9
Pages
468
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: epublishDocument Type: Review
Résumé
Mental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines of evidence suggest more diverse and significant functions of glia with behavior-altering effects. The newly ascribed roles of astrocytes, oligodendrocytes and microglia have led to their examination in brain pathology and mental illnesses. Indeed, abnormalities in glial function, structure and density have been observed in postmortem brain studies of subjects diagnosed with mental illnesses. In this review, we discuss the newly identified functions of glia and highlight the findings of glial abnormalities in psychiatric disorders. We discuss these preclinical and clinical findings implicating the involvement of glial cells in mental illnesses with the perspective that these cells may represent a new target for treatment.
Mots-clé
psychiatric disorder, glia, astrocyte, oligodendrocyte, microglia, NG2 glia, mood, cognition
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/01/2016 17:28
Dernière modification de la notice
16/02/2021 6:27
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