Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins

Détails

ID Serval
serval:BIB_41FE8694771E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins
Périodique
Circulation Research
Auteur⸱e⸱s
Luscher  T. F., Yang  Z., Tschudi  M., von Segesser  L., Stulz  P., Boulanger  C., Siebenmann  R., Turina  M., Buhler  F. R.
ISSN
0009-7330
Statut éditorial
Publié
Date de publication
04/1990
Peer-reviewed
Oui
Volume
66
Numéro
4
Pages
1088-94
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
Endothelin-1 is a 21-amino acid endothelial vasoconstrictor peptide that may be the physiological antagonist of endothelium-derived relaxing factor (EDRF). Endothelin-1 (10(-11)-3 x 10(-7) M) evoked potent contractions of isolated internal mammary arteries, internal mammary veins, and saphenous veins, which were enhanced in internal mammary veins as compared with internal mammary arteries (concentration shift, 6.3-fold; p less than 0.05) but not in the saphenous veins. Endothelial removal augmented the response to the peptide (at 3 x 10(-7) M) in internal mammary arteries (p less than 0.05) but not in veins. In the artery, EDRF released by acetylcholine or bradykinin reversed endothelin-1-induced contractions; in saphenous veins, both agonists were much less effective compared with the artery and veins contracted with norepinephrine (p less than 0.005-0.01). This inhibition of endothelium-dependent relaxations in veins occurred at half-maximal contractions but was most prominent at maximal contractions to the peptide. Nitric oxide similarly inhibited contractions to endothelin-1 and norepinephrine in internal mammary arteries, whereas in veins that were contracted with endothelin-1 but not with norepinephrine, the relaxations were blunted (p less than 0.005). The nitric oxide donor SIN-1 and sodium nitroprusside induced complete relaxations of internal mammary arteries but were less effective in veins contracted with endothelin-1 (p less than 0.005). Thus, in normal human arteries, EDRF inhibits endothelin-1-induced contractions, whereas the peptide specifically attenuates the effects of EDRF and nitrovasodilators in veins. This may be important in pathological conditions associated with increased levels of endothelin-1 and in veins used as coronary bypass grafts.
Mots-clé
Acetylcholine/pharmacology Adult Aged Arteries/drug effects/physiology Bradykinin/pharmacology Drug Interactions Endothelins Endothelium, Vascular/metabolism Female Humans Male Middle Aged Nitric Oxide/*physiology Nitro Compounds/pharmacology Peptides/pharmacology/*physiology Vasoconstriction Vasodilator Agents/pharmacology Veins/drug effects/physiology
Pubmed
Web of science
Création de la notice
14/02/2008 15:17
Dernière modification de la notice
20/08/2019 14:43
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