Early origins of lung disease: towards an interdisciplinary approach.

Détails

ID Serval
serval:BIB_4198D3E504E0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Early origins of lung disease: towards an interdisciplinary approach.
Périodique
European respiratory review
Auteur⸱e⸱s
Ubags NDJ, Alejandre Alcazar M.A., Kallapur S.G., Knapp S., Lanone S., Lloyd C.M., Morty R.E., Pattaroni C., Reynaert N.L., Rottier R.J., Smits H.H., de Steenhuijsen Piters WAA, Strickland D.H., Collins JJP
ISSN
1600-0617 (Electronic)
ISSN-L
0905-9180
Statut éditorial
Publié
Date de publication
30/09/2020
Peer-reviewed
Oui
Volume
29
Numéro
157
Pages
200191
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar "Early origins of lung disease: towards an interdisciplinary approach" (Lisbon, Portugal, November 2019).
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/10/2020 13:39
Dernière modification de la notice
30/04/2022 5:37
Données d'usage