Management of non-functional pancreatic neuroendocrine tumors by endoscopic ultrasound-guided radiofrequency ablation: Retrospective study in two tertiary centers.

Détails

ID Serval
serval:BIB_41768A5E0562
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Management of non-functional pancreatic neuroendocrine tumors by endoscopic ultrasound-guided radiofrequency ablation: Retrospective study in two tertiary centers.
Périodique
Digestive endoscopy
Auteur⸱e⸱s
Marx M., Godat S., Caillol F., Poizat F., Ratone J.P., Pesenti C., Schoepfer A., Hoibian S., Dahel Y., Giovannini M.
ISSN
1443-1661 (Electronic)
ISSN-L
0915-5635
Statut éditorial
Publié
Date de publication
09/2022
Peer-reviewed
Oui
Volume
34
Numéro
6
Pages
1207-1213
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Recently, there has been growing interest in investigating endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) for the management of small non-functional pancreatic neuroendocrine tumors (nf pNETs).
A bicentric retrospective study was performed that included patients with histologically confirmed nf pNETs who were consecutively treated by EUS-RFA between December 2015 and March 2021 at two tertiary referral centers.
In 27 patients (mean age 65.0 years, 52% male), EUS-RFA was successfully performed. All patients had sporadic G1 lesions (mean size 14.0 ± 4.6 mm, 7% uncinated process, 22% head, 11% body, 19% body/tail junction, and 41% tail). Overall, 9/27 lesions (33%) were cystic. The mean hospital stay was 3.2 days. Complete treatment response was confirmed in 25/27 patients (93%) on cross-sectional imaging (mean follow-up 15.7 ± 12.2 months, range 2-41 months). Two patients had two EUS-RFA sessions until complete necrosis was observed. Periprocedural acute pancreatitis occurred in 4/27 (14.8%), three of them were treated by endoscopic cystogastrostomy (11.1%). One patient underwent secondary surgery. The histopathology of the resected specimen revealed 3 mm of residual tumor tissue.
EUS-RFA seems to be a promising treatment strategy for the management of small nf pNETs with excellent efficacy. Further evidence focusing on long-term survival, safety profile and recurrence is needed.
Mots-clé
Acute Disease, Aged, Female, Humans, Male, Neuroectodermal Tumors, Primitive, Neuroendocrine Tumors/diagnostic imaging, Neuroendocrine Tumors/pathology, Neuroendocrine Tumors/surgery, Pancreatic Neoplasms/diagnostic imaging, Pancreatic Neoplasms/pathology, Pancreatic Neoplasms/surgery, Pancreatitis, Radiofrequency Ablation, Retrospective Studies, Treatment Outcome, Ultrasonography, Interventional, endoscopic ultrasound, endoscopic ultrasound-guided radiofrequency ablation, non-functional pancreatic neuroendocrine tumor, pancreatic tumor
Pubmed
Web of science
Création de la notice
03/01/2022 15:37
Dernière modification de la notice
15/09/2022 5:38
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