Chirurgische Therapie von Lebertumoren: Resektion vs. Ablation [Surgical therapy of liver tumors: resection vs. ablation].

Détails

ID Serval
serval:BIB_4170941FD7BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Chirurgische Therapie von Lebertumoren: Resektion vs. Ablation [Surgical therapy of liver tumors: resection vs. ablation].
Périodique
Praxis
Auteur⸱e⸱s
Hübner M., McCormack L., Clavien P.A.
ISSN
1661-8157 (Print)
ISSN-L
1661-8157
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
94
Numéro
33
Pages
1255-1259
Langue
allemand
Notes
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Résumé
A few years ago surgical resection was the only treatment modality for primary and metastatic liver tumors. However, most of the liver tumors are diagnosed at advanced stage and are unresectable. Criteria for unresectability are: uncontrolled extrahepatic disease, extensive intrahepatic tumor growth, insufficient remnant liver volume and severe co-morbid disease. Several therapeutic strategies have been developed to deal with primarily unresectable tumors. A downstaging ("downsizing") of hepatocellular carcinoma (HCC) can be reached by transarterial chemoembolisation (TACE) or local tumor ablation using ethanol injection, cryosurgery and radiofrequency. Preoperative unilateral portal vein embolization resulting in hypertrophy of the remnant liver volume permits to resect some patients with former unresectable liver tumors. Furthermore, liver transplantation is an option for patients with early stage HCC and liver cirrhosis. Preoperative downstaging of colorectal metastases can be achieved with neoadjuvant chemotherapy, whereas TACE, ethanol injection and liver transplantation are no established options for these patients. So far, there are no standardized guidelines for the treatment of patients with unresectable primary or metastatic liver tumors. In this review we aim to describe the different approaches suggested in the literature and to present our algorithms for the management of patients with liver tumors.
Mots-clé
Algorithms, Carcinoma, Hepatocellular/drug therapy, Carcinoma, Hepatocellular/surgery, Chemoembolization, Therapeutic, Chemotherapy, Adjuvant, Colorectal Neoplasms/secondary, Combined Modality Therapy, Humans, Liver Neoplasms/drug therapy, Liver Neoplasms/surgery, Liver Transplantation, Neoadjuvant Therapy
Pubmed
Création de la notice
05/08/2012 11:21
Dernière modification de la notice
20/08/2019 13:41
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