The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction

Détails

ID Serval
serval:BIB_410729CF4436
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction
Périodique
Drug News & Perspectives
Auteur(s)
Pañeda C., Winsky-Sommerer Raphaëlle, Boutrel Benjamin, Lecea Luis de
ISSN
0214-0934
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
18
Numéro
4
Pages
250-255
Notes
SAPHIRID:67383
Résumé
The hypothalamic neuropeptides hypocretins (orexins) play a crucial role in the stability of arousal and alertness. Recent data have raised the hypothesis that hypocretin neurons are also part of the circuitries that mediate the hypothalamic stress response. In particular, we have recently demonstrated that corticotrophin-releasing factor (CRF)-immunoreactive terminals make direct synaptic contacts with hypocretin-expressing neurons and that numerous hypocretinergic neurons express the CRF-R1/2 receptors. Furthermore, CRF excites hypocretinergic cells ex vivo through CRF-R1 receptors. Activation of hypocretinergic neurons in response to acute stress is severely impaired in CRF-R1 knockout mice. Moreover, the stress response is impaired in hypocretin-deficient mice. We propose that upon stressor stimuli, CRF stimulates the release of hypocretins, and this circuit contributes to activation and maintenance of arousal associated with the stress response and addiction. 2005 Prous Science. All rights reserved
Pubmed
Web of science
Création de la notice
11/03/2008 15:07
Dernière modification de la notice
20/08/2019 14:40
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