Acute low single dose of apomorphine reduces periodic limb movements but has no significant effect on sleep arousals: a preliminary report.

Détails

ID Serval
serval:BIB_407197E1A82E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acute low single dose of apomorphine reduces periodic limb movements but has no significant effect on sleep arousals: a preliminary report.
Périodique
Neurophysiologie Clinique = Clinical Neurophysiology
Auteur⸱e⸱s
Haba-Rubio J., Staner L., Cornette F., Lainey E., Luthringer R., Krieger J., Macher J.P.
ISSN
0987-7053 (Print)
ISSN-L
0987-7053
Statut éditorial
Publié
Date de publication
2003
Volume
33
Numéro
4
Pages
180-184
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Résumé
STUDY OBJECTIVES: To investigate the effects of apomorphine on the frequency of periodic limb movements during sleep (PLMS) and on sleep architecture.
DESIGN: Nine patients presenting PLMS (including eight patients with restless legs syndrome) underwent three consecutive night sleep recordings. They received a single dose of 0.5 mg subcutaneous apomorphine at bedtime the third night.
RESULTS: When computing PLMS during four 2-h periods of sleep, a significant period by apomorphine-effect was demonstrated, with a marked reduction of PLMS during the first 4 h post-injection (P < 0.01). No significant differences were found in sleep macroarchitecture between the three recorded nights, excepted a slight reduction in sleep latency during the third night (P < 0.05). Despite the decreased number of PLMS after apomorphine injection, there were significant changes neither in the total number of arousals nor in the index of arousals per hour of sleep.
CONCLUSION: Our results add further support to the dopaminergic hypothesis in the generation of PLMS. The persistence of arousals suggests that they are not simply the consequence of PLMS but a primary phenomenon, not related with the dopaminergic system.
Mots-clé
Apomorphine/therapeutic use, Arousal/drug effects, Dopamine/physiology, Dopamine Agonists/therapeutic use, Electrooculography, Female, Humans, Male, Middle Aged, Nocturnal Myoclonus Syndrome/drug therapy, Nocturnal Myoclonus Syndrome/physiopathology, Polysomnography, Sleep/physiology, Sleep Wake Disorders/physiopathology, Synaptic Transmission/drug effects, Synaptic Transmission/physiology
Pubmed
Création de la notice
24/04/2016 10:59
Dernière modification de la notice
19/11/2019 7:26
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