Recombinant immunoglobulin A: powerful tools for fundamental and applied research

Détails

ID Serval
serval:BIB_3FFD8C198215
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Recombinant immunoglobulin A: powerful tools for fundamental and applied research
Périodique
Trends in Biotechnology
Auteur⸱e⸱s
Corthesy  B.
ISSN
0167-7799 (Print)
Statut éditorial
Publié
Date de publication
02/2002
Volume
20
Numéro
2
Pages
65-71
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Résumé
The use of monoclonal antibodies has become routine in research and diagnostic laboratories but the potential level of antibodies in use in public health and medical applications is still far from its maximum. From a clinical perspective, topical immunotherapy of mucosal surfaces with monoclonal antibodies can block entry and transmission of bacteria, viruses, fungi and parasites that infect humans, and defeat some key strategies, evolved by many pathogens, to evade the host immune system. The chief antibody at mucosal surfaces is secretory immunoglobulin A (SIgA), a multi-polypeptide complex originating from two cell types. The recent design of heterologous expression systems, coupled with modern biotechnology processes, should form a sound basis for studying the functional properties of SIgAs and evaluate their value as biotherapeutics. Here, we discuss the principles underlying mucosal immunity and review the application of recombinant SIgA to the dissection of mechanisms in passive and active protection at mucosal surfaces.
Mots-clé
Animals Antibodies, Monoclonal/chemistry/immunology Bacterial Infections/prevention & control Biotechnology/trends Humans *Immunity, Mucosal Immunization, Passive Immunoglobulin A/immunology Immunoglobulin A, Secretory/*biosynthesis/chemistry/immunology Immunologic Techniques/trends Mucous Membrane/immunology Recombinant Proteins/biosynthesis/chemistry/immunology Structure-Activity Relationship Surface Properties Vaccination
Pubmed
Web of science
Création de la notice
25/01/2008 15:53
Dernière modification de la notice
20/08/2019 14:37
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