Novel Insights into Cell Entry of Emerging Human Pathogenic Arenaviruses.

Détails

ID Serval
serval:BIB_3FEF5E505811
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Novel Insights into Cell Entry of Emerging Human Pathogenic Arenaviruses.
Périodique
Journal of molecular biology
Auteur(s)
Fedeli C., Moreno H., Kunz S.
ISSN
1089-8638 (Electronic)
ISSN-L
0022-2836
Statut éditorial
Publié
Date de publication
22/06/2018
Peer-reviewed
Oui
Volume
430
Numéro
13
Pages
1839-1852
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
Publication Status: ppublish
Résumé
Viral hemorrhagic fevers caused by emerging RNA viruses of the Arenavirus family are among the most devastating human diseases. Climate change, global trade, and increasing urbanization promote the emergence and re-emergence of these human pathogenic viruses. Emerging pathogenic arenaviruses are of zoonotic origin and reservoir-to-human transmission is crucial for spillover into human populations. Host cell attachment and entry are the first and most fundamental steps of every virus infection and represent major barriers for zoonotic transmission. During host cell invasion, viruses critically depend on cellular factors, including receptors, co-receptors, and regulatory proteins of endocytosis. An in-depth understanding of the complex interaction of a virus with cellular factors implicated in host cell entry is therefore crucial to predict the risk of zoonotic transmission, define the tissue tropism, and assess disease potential. Over the past years, investigation of the molecular and cellular mechanisms underlying host cell invasion of human pathogenic arenaviruses uncovered remarkable viral strategies and provided novel insights into viral adaptation and virus-host co-evolution that will be covered in the present review.
Mots-clé
Animals, Arenaviridae Infections/transmission, Arenaviridae Infections/virology, Arenavirus/genetics, Arenavirus/physiology, Host Microbial Interactions, Humans, Viral Tropism, Virus Attachment, Virus Internalization, Zoonoses/transmission, Zoonoses/virology, arenavirus, receptor, tropism, viral entry, zoonosis
Pubmed
Web of science
Création de la notice
03/05/2018 18:30
Dernière modification de la notice
20/08/2019 14:37
Données d'usage