Cancer and inflammation: promise for biologic therapy.

Détails

ID Serval
serval:BIB_3FE6D5E1CB50
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cancer and inflammation: promise for biologic therapy.
Périodique
Journal of Immunotherapy
Auteur(s)
Demaria S., Pikarsky E., Karin M., Coussens L.M., Chen Y.C., El-Omar E.M., Trinchieri G., Dubinett S.M., Mao J.T., Szabo E., Krieg A., Weiner G.J., Fox B.A., Coukos G., Wang E., Abraham R.T., Carbone M., Lotze M.T.
ISSN
1537-4513 (Electronic)
ISSN-L
1524-9557
Statut éditorial
Publié
Date de publication
2010
Volume
33
Numéro
4
Pages
335-351
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; ReviewPublication Status: ppublish
Résumé
Cancers often arise as the end stage of inflammation in adults, but not in children. As such there is a complex interplay between host immune cells during neoplastic development, with both an ability to promote cancer and limit or eliminate it, most often complicit with the host. In humans, defining inflammation and the presence of inflammatory cells within or surrounding the tumor is a critical aspect of modern pathology. Groups defining staging for neoplasms are strongly encouraged to assess and incorporate measures of the presence of apoptosis, autophagy, and necrosis and also the nature and quality of the immune infiltrate. Both environmental and genetic factors enhance the risk of cigarette smoking, Helicobacter pylori, hepatitis B/C, human papilloma virus, solar irradiation, asbestos, pancreatitis, or other causes of chronic inflammation. Identifying suitable genetic polymorphisms in cytokines, cytokine receptors, and Toll-like receptors among other immune response genes is also seen as high value as genomic sequencing becomes less expensive. Animal models that incorporate and assess not only the genetic anlagen but also the inflammatory cells and the presence of microbial pathogens and damage-associated molecular pattern molecules are necessary. Identifying micro-RNAs involved in regulating the response to damage or injury are seen as highly promising. Although no therapeutic strategies to prevent or treat cancers based on insights into inflammatory pathways are currently approved for the common epithelial malignancies, there remains substantial interest in agents targeting COX2 or PPARgamma, ethyl pyruvate and steroids, and several novel agents on the horizon.
Mots-clé
Adaptive Immunity, Adult, Animals, Biological Therapy/trends, Child, Disease Models, Animal, Humans, Immunity, Innate, Inflammation, Neoplasms/genetics, Neoplasms/immunology
Pubmed
Web of science
Création de la notice
14/10/2014 12:42
Dernière modification de la notice
20/08/2019 14:37
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