Irinotecan-induced colitis

Détails

ID Serval
serval:BIB_3F146B1BFE34
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Irinotecan-induced colitis
Périodique
International journal of surgical pathology
Auteur⸱e⸱s
Sandmeier  D., Chaubert  P., Bouzourene  H.
ISSN
1066-8969 (Print)
Statut éditorial
Publié
Date de publication
2005
Volume
13
Numéro
2
Pages
215-218
Notes
PT - Case Reports PT - Journal Article
Résumé
Irinotecan (CPT-11) is a chemotherapeutic drug used to treat tumors by acting on malignant cells through inhibition of DNA topoisomerase I and inducing premature apoptosis. Major toxic effects of Irinotecan are myelosuppression and gastrointestinal (GI) toxicity, which limits the dose of administration, particularly severe diarrhea with a delay of onset. However, according to the literature, serious GI side effects are uncommon, comprising 3% of the reported cases. The mechanism of Irinotecan-induced delayed diarrhea is unknown and unpredictable. To our knowledge, this is the first case of colitis associated with Irinotecan administration for temporal glioblastoma documented by biopsies. The histopathologic findings are described and the potential mechanisms inducing such lesions are discussed
Mots-clé
Aged/Antineoplastic Agents,Phytogenic/adverse effects/Apoptosis/drug effects/Biological Markers/metabolism/Biopsy/Brain Neoplasms/therapy/Camptothecin/analogs & derivatives/Colitis/chemically induced/complications/Pathology/Colon/DNA Topoisomerases,Type I/antagonists & inhibitors/Diarrhea/Glioblastoma/Humans/Ileum/Immunoenzyme Techniques/Male
Pubmed
Web of science
Création de la notice
29/01/2008 19:34
Dernière modification de la notice
20/08/2019 14:36
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