A gut feeling of the PXR, PPAR and NF-kappaB connection.

Détails

ID Serval
serval:BIB_3F0C91E3D51D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
A gut feeling of the PXR, PPAR and NF-kappaB connection.
Périodique
Journal of Internal Medicine
Auteur(s)
Wahli W.
ISSN
1365-2796[electronic], 0954-6820[linking]
Statut éditorial
Publié
Date de publication
2008
Volume
263
Numéro
6
Pages
613-619
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Bowel diseases reveal the complex interplay of sensing and signalling pathways in maintaining healthy homeostasis of the intestine. Recent studies of the xenobiotic nuclear receptor, pregnane X receptor and the inflammatory mediator nuclear transcription factor kappaB (NF-kappaB) reveal a functional link between xenobiotic neutralization and inflammation and explain how certain xenobiotics can affect the immune response. Furthermore, another nuclear receptor, peroxisome proliferator-activated receptor gamma (PPAR gamma) has been shown to produce beneficial effects in experimental inflammatory bowel diseases by repression of NF-kappaB thereby reducing inflammation, whilst its close relative PPAR beta/delta appears at a central position in signalling pathways involved in the progression of colon cancer. Recently accumulated knowledge on the action of these nuclear receptors and NF-kappaB in intestinal homeostasis may provide the rationale for the development of innovative treatment strategies with selective receptor modulators.
Mots-clé
Cell Transformation, Neoplastic/metabolism, Colonic Neoplasms/physiopathology, Humans, Inflammatory Bowel Diseases/physiopathology, NF-kappa B/physiology, Peroxisome Proliferator-Activated Receptors/physiology, Receptors, Steroid/physiology, Signal Transduction, Xenobiotics/toxicity
Pubmed
Web of science
Création de la notice
29/01/2009 22:14
Dernière modification de la notice
20/08/2019 13:36
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