Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV

Détails

ID Serval
serval:BIB_3F0888547271
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV
Périodique
Nature
Auteur(s)
Pantaleo  G., Demarest  J. F., Soudeyns  H., Graziosi  C., Denis  F., Adelsberger  J. W., Borrow  P., Saag  M. S., Shaw  G. M., Sekaly  R. P., Fauci  A.S.
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
08/1994
Volume
370
Numéro
6489
Pages
463-7
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug 11
Résumé
A SIGNIFICANT proportion (up to 70%) of individuals experience an acute clinical syndrome of varying severity associated with primary infection with the human immunodeficiency virus (HIV). We report here studies on six individuals who showed an acute HIV syndrome which generally resolved within four weeks, concomitant with a dramatic downregulation of viraemia. To characterize the T-cell-mediated primary immune response to HIV, we used combined semiquantitative polymerase chain reaction assay and cytofluorometry to analyse the T-cell antigen receptor repertoire in sequential peripheral blood mononuclear cells from the patients. We found major oligoclonal expansions in a restricted set of variable-domain beta-chain (V beta) families. Cells expressing the expanded V beta s predominantly expressed the CD8 T-cell differentiation antigen and mediated HIV-specific cytotoxicity. Major oligoclonal expansions of these CD8+ T lymphocytes may represent an important component of the primary immune response to viral infections and may help to clarify both the immunopathogenic and the protective mechanisms of HIV infection.
Mots-clé
Adolescent Adult Amino Acid Sequence *Antigens, CD8 Cell Line, Transformed Cells, Cultured Clone Cells Cytotoxicity, Immunologic Dna Female Flow Cytometry HIV/*immunology HIV Infections/*immunology Humans Immunogenetics Immunophenotyping Male Molecular Sequence Data Polymerase Chain Reaction Prospective Studies Receptors, Antigen, T-Cell, alpha-beta/*genetics T-Lymphocyte Subsets/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 14:58
Dernière modification de la notice
20/08/2019 13:36
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