Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function

Détails

ID Serval
serval:BIB_3EF5245DA251
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function
Périodique
Journal of the American College of Cardiology
Auteur(s)
Schindler  T. H., Cardenas  J., Prior  J. O., Facta  A. D., Kreissl  M. C., Zhang  X. L., Sayre  J., Dahlbom  M., Licinio  J., Schelbert  H. R.
ISSN
1558-3597
Statut éditorial
Publié
Date de publication
03/2006
Peer-reviewed
Oui
Volume
47
Numéro
6
Pages
1188-95
Notes
Journal Article
Research Support, N.I.H., Extramural --- Old month value: Mar 21
Résumé
OBJECTIVES: We sought to evaluate effects of obesity, insulin resistance, and inflammation on coronary circulatory function and its relationship to leptin plasma levels. BACKGROUND: It is not known whether obesity, commonly paralleled by insulin resistance, inflammation, and leptin, is independently associated with coronary circulatory dysfunction. METHODS: Myocardial blood flow (MBF) responses to cold pressor test (CPT) and pharmacologic vasodilation was measured with positron emission tomography and 13N-ammonia. Study participants were divided into three groups based on their body mass index (BMI, kg/m2): control, 20 < or = BMI <25 (n = 19); overweight, 25 < or = BMI <30 (n = 21); and obese, BMI >30 (n = 32). RESULTS: Body mass index was significantly correlated to the Homeostasis Model Assessment Index of insulin resistance and C-reactive protein levels (r = 0.60 and r = 0.47, p < 0.0001). Compared with control subjects, endothelium-related change in MBF (DeltaMBF) to CPT progressively declined in overweight and obese groups (0.32 +/- 0.09 vs. 0.21 +/- 0.19 and 0.07 +/- 0.16 ml/g/min; p < 0.03 and p < 0.0001). The dipyridamole-induced total vasodilator capacity was significantly lower in obese than in control subjects (1.77 +/- 0.51 vs. 2.04 +/- 0.37 ml/g/min, p < 0.02). On multivariate analysis, BMI (p < 0.012) and age (p < 0.035) were significant independent predictors of DeltaMBF. Finally, only in the obese group leptin plasma levels significantly correlated with DeltaMBF (r = 0.37, p < 0.036). CONCLUSIONS: Increased body weight is independently associated with abnormal coronary circulatory function that progresses from an impairment in endothelium-related coronary vasomotion in overweight individuals to an impairment of the total vasodilator capacity in obese individuals. The findings that elevated leptin plasma levels in patients that are obese might exert beneficial effects on the coronary endothelium to counterbalance the adverse effects of increases in body weight on coronary circulatory function should be tested.
Mots-clé
Adult Coronary Circulation/*physiology Female Humans Inflammation/*blood/*physiopathology *Insulin Resistance Leptin/*blood Male Obesity/*blood/*physiopathology *Overweight
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 16:38
Dernière modification de la notice
20/08/2019 13:35
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