Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression.

Détails

ID Serval
serval:BIB_3EDC16F07D77
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression.
Périodique
Seminars in Cancer Biology
Auteur⸱e⸱s
Lefort K., Dotto G.P.
ISSN
1044-579X (Print)
ISSN-L
1044-579X
Statut éditorial
Publié
Date de publication
2004
Volume
14
Numéro
5
Pages
374-386
Langue
anglais
Résumé
Oncogenesis is closely linked to abnormalities in cell differentiation. Notch signaling provides an important form of intercellular communication involved in cell fate determination, stem cell potential and differentiation. Here we review the role of this pathway in the integrated growth/differentiation control of the keratinocyte cell type, and the maintenance of normal skin homeostasis. In parallel with the pro-differentiation function of Notch1 in keratinocytes, we discuss recent evidence pointing to a tumor suppressor function of this gene in both mouse skin and human cervical carcinogenesis. The possibility that Notch signaling elicits signals with a duality of growth positive and negative function will be discussed.
Mots-clé
Animals, Cell Differentiation, Cell Division, Keratinocytes/cytology, Membrane Proteins/metabolism, Mice, Receptors, Notch, Signal Transduction
Pubmed
Web of science
Création de la notice
24/01/2008 14:58
Dernière modification de la notice
20/08/2019 13:35
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