Niedrig-gradige Gliome im Erwachsenenalter [Low-grade gliomas in adults].

Détails

ID Serval
serval:BIB_3ECFB10F1079
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Niedrig-gradige Gliome im Erwachsenenalter [Low-grade gliomas in adults].
Périodique
Praxis
Auteur(s)
Kratzsch T., Gautschi O.P., Kuhn S.A., Hottinger A.F., Hildebrandt G., Stienen M.N.
ISSN
1661-8157 (Print)
ISSN-L
1661-8157
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
103
Numéro
23
Pages
1385-1396
Langue
allemand
Notes
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Résumé
Low-grade gliomas (LGG) are brain tumors with a low or intermediate biological aggressiveness. According to histopathological features, they are further specified as grade I or II by WHO criteria. Diffuse astrocytomas, oligodendrogliomas, and mixed gliomas are the most common LGG. They mainly affect young patients in their 3rd to 5th decade and often manifest with epileptic seizures. A macroscopically complete or near-complete tumor resection that does not induce additional neurological deficits, is recommended as first line therapy in surgically accessible tumors, as a significant benefit for overall survival has been demonstrated. The indication for adjuvant chemo- or radiotherapy must be discussed interdisciplinary in each case. MGMT promotor methylation, LOH 1p/19q, as well as the status of somatic mutations within IDH1/2 gene constitute biomarkers that may predict response to adjuvant therapy and may correlate to overall survival. These and other biomarkers could be of benefit in future managing plans to offer patients with LGG an individually tailored, optimal treatment.
Mots-clé
Adult, Biopsy, Brain/pathology, Brain Neoplasms/pathology, Brain Neoplasms/therapy, Chemotherapy, Adjuvant, Combined Modality Therapy, Female, Glioma/diagnosis, Glioma/pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Postoperative Complications/diagnosis, Prognosis, Radiotherapy, Adjuvant, Tomography, X-Ray Computed
Pubmed
Création de la notice
18/10/2016 16:32
Dernière modification de la notice
20/08/2019 13:35
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