Pharmacological interference with 123I-metaiodobenzylguanidine: a limitation to developing cardiac innervation imaging in clinical practice?

Détails

ID Serval
serval:BIB_3ECC13ECA770
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pharmacological interference with 123I-metaiodobenzylguanidine: a limitation to developing cardiac innervation imaging in clinical practice?
Périodique
European review for medical and pharmacological sciences
Auteur(s)
Stefanelli A., Treglia G., Bruno I., Rufini V., Giordano A.
ISSN
1128-3602 (Print)
ISSN-L
1128-3602
Statut éditorial
Publié
Date de publication
05/2013
Peer-reviewed
Oui
Volume
17
Numéro
10
Pages
1326-1333
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
(123)I-metaiodo-benzylguanidine (MIBG) scintigraphy is considered a valid imaging test to evaluate the cardiac sympathetic nervous system. However, scientific literature showed that some drugs are able to or are expected to interfere with MIBG uptake. Thirty years after introduction of the method and over 15 years since the appearance of the first document on pharmacological interference with MIBG, an update on this issue has become necessary.
The aims of this review paper are: (1) to identify the pharmacological basis of interference of a variety of substances with MIBG uptake; and (2) to update the list of drugs that definitely interfere with MIBG on the grounds of evidence in the literature.
A MEDLINE search was conducted. Scientific studies, case report and review articles were collected. Papers published demonstrating drugs interfering with MIBG uptake were evaluated.
Drugs may interact with MIBG uptake by 5 mechanism: (1) type-1 uptake inhibition; (2) inhibition of active transport to vesicles; (3) competition in transport to vesicles; (4) depletion of neurosecretory vesicle content; (5) calcium-mediated mechanism. We find that drugs like cocaine, antidepressants, some antipsychotic, tramadol, labetalol, sympatho-mimetics, reserpine and some calcium antagonists (as diltiazem, verapamil and nifedipine) do interfere with MIBG uptake. On the other hand, we find that controversial data are available on scientific literature regarding digoxin and amiodarone.
A compiled statement of MIBG interfering medicines is now recommended to help nuclear medicine physicians in clinical practice to avoid potential pitfalls and improve the efficacy of (123)I-MIBG scintigraphy as a diagnostic tool.

Mots-clé
3-Iodobenzylguanidine/pharmacokinetics, Amiodarone/pharmacology, Antidepressive Agents, Tricyclic/pharmacology, Heart/innervation, Humans, Iodine Radioisotopes, Radiopharmaceuticals, Reserpine/pharmacology, Tramadol/pharmacology
Pubmed
Web of science
Création de la notice
20/08/2017 19:33
Dernière modification de la notice
20/08/2019 13:35
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