Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia.

Détails

ID Serval
serval:BIB_3EAE65A54E34
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia.
Périodique
Science
Auteur(s)
Tucci S., Vohr S.H., McCoy R.C., Vernot B., Robinson M.R., Barbieri C., Nelson B.J., Fu W., Purnomo G.A., Sudoyo H., Eichler E.E., Barbujani G., Visscher P.M., Akey J.M., Green R.E.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
03/08/2018
Peer-reviewed
Oui
Volume
361
Numéro
6401
Pages
511-516
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
Flores Island, Indonesia, was inhabited by the small-bodied hominin species <i>Homo floresiensis</i> , which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where <i>H. floresiensis</i> was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.
Pubmed
Web of science
Création de la notice
16/08/2018 7:46
Dernière modification de la notice
20/08/2019 13:35
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