Effect of thyroid hormones administration on urinary endogenous steroid profile of the athlete biological passport.

Détails

ID Serval
serval:BIB_3E8D7F33FA86
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of thyroid hormones administration on urinary endogenous steroid profile of the athlete biological passport.
Périodique
Drug testing and analysis
Auteur⸱e⸱s
Martínez Brito D., de la Torre X., Botrè F.
ISSN
1942-7611 (Electronic)
ISSN-L
1942-7603
Statut éditorial
Publié
Date de publication
2023
Peer-reviewed
Oui
Volume
15
Numéro
11-12
Pages
1361-1370
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
This work focused on the possible alterations of the markers of the steroidal module of the athlete biological passport, considering samples of athletes declaring and not-declaring the supplementation of thyroid hormones (TH) in the Doping Control Form (DCF). Concentrations of 5α-androstane-3α,17β-diol (5α-Adiol), 5β-androstane-3α,17β-diol (5β-Adiol), testosterone (T), androsterone (A), etiocholanolone (Etio), epitestosterone (E), pregnanediol (PD), dehydroepiandrosterone (DHEA), and 11β-hydroxy-androsterone (OHA) were calculated using internal standards and external calibration by gas chromatography-tandem mass spectrometry. Also, ratios between the above biomarkers were also estimated. The data set was composed of samples from females and males declaring and not-declaring TH supplementation in the DCF. To corroborate these observations, a controlled urinary excretion study was carried out with multiple doses of sodium liothyronine (T3). Female data showed significant differences for the concentrations of 5α-Adiol, A, DHEA, E, OHA, and T and the ratio A/Etio between FD and FND groups, whereas the male groups only showed significant differences in OHA concentration. In both cases, males and females declaring the consumption of levothyroxine showed narrower data distribution and diminished percentiles from 17% to 67% with respect to the not-declaring corresponding groups (p < 0.05). Concentrations of 5α-metabolites showed a higher depression for the FND, and both FD and MD groups showed a peculiar behavior for the PD concentrations. The controlled study agreed with the observations, mainly for the female group with significant differences for concentrations of E, Etio, 5α-Adiol, and 5β-Adiol after TH administration. The interpretation of the steroid markers of the ABP should consider TH administrations.
Mots-clé
Humans, Male, Female, Androsterone, Gas Chromatography-Mass Spectrometry, Testosterone/urine, Steroids/urine, Athletes, Doping in Sports, Etiocholanolone, Dehydroepiandrosterone/urine, athlete biological passport, steroid profile, thyroid hormones, urine
Pubmed
Web of science
Création de la notice
04/12/2023 15:15
Dernière modification de la notice
22/12/2023 8:49
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