Friedreich's ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families

Détails

ID Serval
serval:BIB_3E6EEF2F4E82
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Friedreich's ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families
Périodique
Neurology
Auteur(s)
Ben Hamida  M., Belal  S., Sirugo  G., Ben Hamida  C., Panayides  K., Ionannou  P., Beckmann  J., Mandel  J. L., Hentati  F., Koenig  M., Middleton L.
ISSN
0028-3878 (Print)
Statut éditorial
Publié
Date de publication
11/1993
Volume
43
Numéro
11
Pages
2179-83
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Friedreich's ataxia (FA) is an autosomal recessive neurodegenerative disorder, the disease locus (FRDA) of which has been assigned to 9q13-q21.1 by genetic linkage analysis in affected families. We report two large inbred Tunisian families with FA manifestations that did not show the expected linkage. The disease locus could be excluded from a large (12 cMo) region around FRDA. This is the first report providing evidence for nonallelic genetic heterogeneity for the FA clinical phenotype. On subsequent analysis, all patients had very low levels of serum vitamin E whereas the parents and healthy sibs had normal vitamin E levels. This establishes that the selective vitamin E deficiency with normal fat absorption is an autosomal recessive trait, which is associated in the two families reported here with the FA phenotype.
Mots-clé
Adult *Chromosomes, Human, Pair 9 Consanguinity Female Friedreich Ataxia/complications/*genetics Humans Linkage (Genetics) Lod Score Male Phenotype Tunisia Vitamin E Deficiency/complications/*genetics
Pubmed
Web of science
Création de la notice
25/01/2008 16:18
Dernière modification de la notice
20/08/2019 13:35
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