Sex differences in patients receiving anticoagulant therapy for venous thromboembolism.

Détails

ID Serval
serval:BIB_3E6684B47766
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sex differences in patients receiving anticoagulant therapy for venous thromboembolism.
Périodique
Medicine
Auteur(s)
Blanco-Molina A., Enea I., Gadelha T., Tufano A., Bura-Riviere A., Di Micco P., Bounameaux H., González J., Villalta J., Monreal M.
Collaborateur(s)
RIETE Investigators
Contributeur(s)
Arcelus JI., Ballaz A., Barba R., Barrón M., Barrón-Andrés B., Bascuñana J., Bedate P., Blanco-Molina A., Bueso T., Casado I., Conget F., del Molino F., del Toro J., Falgá C., Fernández-Capitán C., Fuentes MI., Gallego P., Garcia-Bragado F., Gómez V., González J., González-Bachs E., Grau E., Guil M., Guijarro R., Gutiérrez J., Hernández L., Hernández-Huerta S., Hernando-López E., Jaras MJ., Jiménez D., Lobo JL., López-Jiménez L., López-Reyes R., López-Sáez JB., Lorente MA., Lorenzo A., Luque JM., Madridano O., Maestre A., Marchena PJ., Martín M., Monreal M., Muñoz FJ., Nauffal D., Nieto JA., Núñez MJ., Ogea JL., Pedrajas JM., Peris ML., Porras JA., Raissouni N., Riera-Mestre A., Rivas A., Rodríguez-Dávila MA., Román P., Rosa V., Ruiz-Giménez N., Sahuquillo JC., Samperiz A., Sánchez Muñoz-Torrero JF. , Soler S., Suriñach JM., Tiberio G., Tirado R., Tolosa C., Trujillo-Santos J., Uresandi F., Valdés M., Valero B., Valle R., Vela J., Vidal G., Villalobos A., Villalta J., Gadelha T., Malý R., Hirmerova J., Kaletova M., Tomko T., Bertoletti L., Bura-Riviere A., Farge-Bancel D., Grange C., Hij A., Mahe I., Merah A., Quere I., Schellong S., Babalis D., Papadakis M., Tzinieris I., Braester A., Brenner B., Tzoran I., Zeltser D., Bacciottini N., Barillari G., Bucherini E., Cattabiani C., Ciammaichella M., Dalla Valle F., Di Micco P., Duce R., Giorgi-Pierfranceschi M., Gussoni G., Maida R., Pasca S., Piovella C., Poggio R., Prandoni P., Quintavalla R., Rocci A., Rota L., Schenone A., Tiraferri E., Tonello D., Tufano A., Visonà A., Zalunardo B., Bastos MS., Brinquinho M., GoS ncalves F., Santos M., Bosevski M., Kovacevic D., Alatri A., Aujeski D., Bounameaux H., Calanca L., Mazzolai L.
ISSN
1536-5964 (Electronic)
ISSN-L
0025-7974
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
93
Numéro
17
Pages
309-317
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
In patients with venous thromboembolism (VTE), the outcome during the course of anticoagulant therapy may differ according to the patient's sex. We used the RIETE (Registro Informatizado Enfermedad TromboEmbólica) database to compare the rate of VTE recurrences, major bleeding, and mortality due to these events according to sex.As of August 2013, 47,499 patients were enrolled in RIETE, of whom 24,280 (51%) were women. Women were older, more likely presented with pulmonary embolism (PE), and were more likely to have recent immobilization but less likely to have cancer than men. During the course of anticoagulation (mean duration: 253 d), 659 patients developed recurrent deep vein thrombosis (DVT), 576 recurrent PE, 1368 bled, and 4506 died. Compared with men, women had a lower rate of DVT recurrences (hazard ratio [HR]: 0.78; 95% confidence interval [CI]: 0.67-0.91), a similar rate of PE recurrences (HR: 0.98; 95% CI: 0.83-1.15), a higher rate of major bleeding (HR: 1.21; 95% CI: 1.09-1.35), and higher mortality due to PE (HR: 1.24; 95% CI: 1.04-1.47). On multivariable analysis, any influence of sex on the risk for recurrent DVT (HR: 0.88; 95% CI: 0.75-1.03), major bleeding (HR: 1.10; 95% CI: 0.98-1.24), or fatal PE (HR: 1.01; 95% CI: 0.84-1.22) was no longer statistically significant.In conclusion, women had fewer DVT recurrences and more bleeds than men during the course of anticoagulation. These differences were not due to sex, but very likely to other patient characteristics more common in female patients and differences in treatment choice.
Mots-clé
Adult, Aged, Aged, 80 and over, Anticoagulants/therapeutic use, Female, Hemorrhage/chemically induced, Hemorrhage/mortality, Humans, Male, Middle Aged, Pulmonary Embolism/mortality, Recurrence, Sex Factors, Venous Thromboembolism/drug therapy, Venous Thromboembolism/mortality
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/02/2015 10:30
Dernière modification de la notice
02/06/2020 14:06
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