High mobility group box 1 protein (HMGB-1): a pathogenic role in preeclampsia?

Détails

ID Serval
serval:BIB_3E53EE74E4DA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
High mobility group box 1 protein (HMGB-1): a pathogenic role in preeclampsia?
Périodique
Placenta
Auteur(s)
Pradervand P.A., Clerc S., Frantz J., Rotaru C., Bardy D., Waeber B., Liaudet L., Vial Y., Feihl F.
ISSN
1532-3102 (Electronic)
ISSN-L
0143-4004
Statut éditorial
Publié
Date de publication
2014
Volume
35
Numéro
9
Pages
784-786
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We evaluated whether preeclampsia is associated with elevated circulating levels of High mobility group box 1 protein (HMGB-1), a nuclear protein with proinflammatory effects when released extracellularly. We enrolled 48 women, 32 in third trimester pregnancy (16 with, 16 without preeclampsia), and 16 healthy non pregnant. In the peripheral blood of pregnant women, HMGB-1 concentration was assessed serially, before and after delivery. With or without preeclampsia, third trimester pregnancy was associated with elevated levels of HMGB-1. This elevation is exaggerated in preeclampsia. The source of HMGB-1 observed in these conditions is likely to involve tissues other than the placenta itself.
Pubmed
Web of science
Création de la notice
01/09/2014 10:35
Dernière modification de la notice
20/08/2019 14:35
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