Defining the frontiers between antifungal resistance, tolerance and the concept of persistence.

Détails

Ressource 1Télécharger: Drug Resist Updat 2015 Delarze.pdf (748.31 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_3E0955499024
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Defining the frontiers between antifungal resistance, tolerance and the concept of persistence.
Périodique
Drug Resistance Updates : Reviews and Commentaries In Antimicrobial and Anticancer Chemotherapy
Auteur⸱e⸱s
Delarze E., Sanglard D.
ISSN
1532-2084 (Electronic)
ISSN-L
1368-7646
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
23
Pages
12-19
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
A restricted number of antifungal agents are available for the therapy of fungal diseases. With the introduction of epidemiological cut-off values for each agent in important fungal pathogens based on the distribution of minimal inhibitory concentration (MIC), the distinction between wild type and drug-resistant populations has been facilitated. Antifungal resistance has been described for all currently available antifungal agents in several pathogens and most of the associated resistance mechanisms have been deciphered at the molecular level. Clinical breakpoints for some agents have been proposed and can have predictive value for the success or failure of therapy. Tolerance to antifungals has been a much more ignored area. By definition, tolerance operates at antifungal concentrations above individual intrinsic inhibitory values. Important is that tolerance to antifungal agents favours the emergence of persister cells, which are able to survive antifungal therapy and can cause relapses. Here we will review the current knowledge on antifungal tolerance, its potential mechanisms and also evaluate the role of antifungal tolerance in the efficacy of drug treatments.
Mots-clé
Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Dose-Response Relationship, Drug, Drug Resistance, Fungal/physiology, Drug Tolerance/physiology, Echinocandins/pharmacology, Flucytosine/pharmacology, Fungi/drug effects, Fungi/pathogenicity, Host-Pathogen Interactions, Humans, Microbial Sensitivity Tests, Mycoses/drug therapy, Mycoses/microbiology, Triazoles/pharmacology
Pubmed
Web of science
Création de la notice
04/10/2016 16:45
Dernière modification de la notice
22/01/2020 7:08
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