Late-onset cytomegalovirus disease in patients with solid organ transplant.

Détails

ID Serval
serval:BIB_3DEB4A4DB321
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Late-onset cytomegalovirus disease in patients with solid organ transplant.
Périodique
Current Opinion in Infectious Diseases
Auteur⸱e⸱s
Meylan P.R., Manuel O.
ISSN
0951-7375
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
20
Numéro
4
Pages
412-418
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
PURPOSE OF REVIEW: To review existing data regarding late cytomegalovirus disease occurring after antiviral prophylaxis. RECENT FINDINGS: There is a continued debate as to the respective merits of the preemptive and the prophylactic approach to prevent cytomegalovirus disease after transplantation. Arguably, by allowing some infection, the preemptive approach helps build immunity in contrast to prophylaxis, explaining the occurrence of late cytomegalovirus disease in the latter approach. No study comparing directly both approaches is large enough to definitely determine whether the preemptive approach leads to a faster development of immune response protective from late disease nor whether late disease is clinically different after prophylaxis compared to early cytomegalovirus diseases. While risk factors for late cytomegalovirus disease all point to a delay in mounting immune responses, there are no identified markers that would help predict the risk for late disease at the time of prophylaxis discontinuation. Various approaches to prevent late cytomegalovirus disease have been developed: prolonged prophylaxis, microbiological surveillance and preemptive treatment after prophylaxis discontinuation. Considering the identifying risk factors for late disease, it would also make sense to envision vaccinating cytomegalovirus-seronegative recipients. SUMMARY: The best approach to prevent or manage late cytomegalovirus disease associated with cytomegalovirus prophylaxis remains to be defined.
Mots-clé
Antiviral Agents, Cytomegalovirus, Cytomegalovirus Infections, Humans, Organ Transplantation, Postoperative Complications, Risk Factors, Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 14:32
Dernière modification de la notice
20/08/2019 13:34
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